Improved Nasal Volume Utilizing Hyperosmotic Saline Xylitol Mixture (Effective Alternative or Adjunct to Decongestants and Antihistamines) – 2019
High Viral Load in the Nose – Mar. 2020
In this correspondence, researchers shared their research which showed that the nose has the highest viral load of SARS-CoV-2 than elsewhere in the body when infected with the virus.
Mapping How SARS-CoV-2 Infects the Body – May 2020
In this study done at UNC Chapel Hill, researchers found that the SARS-CoV-2 virus first infects the body through the nose, establishes itself there, and then progresses into the airway and lungs.
The Three Stages of SARS-CoV-2 Infection – Jul. 2020
Benefits and Safety of Nasal Saline Irrigations in a Pandemic—Washing SARS-CoV-2 Away – Jul. 2020
Anti-Adherence of SARS-CoV-2 Virus – Aug. 2020
Using Nasal Sprays to Combat SARS-CoV-2 – Sept. 2020
Nasal Irrigation Reduces Symptoms Related to SARS-CoV-2 – Sept. 2020
Kimura, K. S., et al., (2020). Interim analysis of an open-label randomized controlled trial evaluating nasal irrigations in non-hospitalized patients with coronavirus disease 2019. International Forum of Allergy & Rhinology, 10(12), 1325–1328.
Potential Role of Xylitol Plus Grapefruit Seed Extract Nasal Spray Solution with SARS-CoV-2: Case Series – Nov. 2020
Xylitol’s Method of Action against SARS-CoV-2 – Nov. 2020
Deactivation of SARS-CoV-2 with Xlear Nasal Spray – Nov. 2020
Further Evidence of Xylitol’s Effectiveness Against SARS-CoV-2, H1N1, and Other Viruses – Jan. 2021
Comprehensive Literature Review of Intranasal Therapy Against SARS-CoV-2 – Jan. 2021
Inhibition of severe acute respiratory syndrome coronavirus 2 replication by hypertonic saline solution in lung and kidney epithelial cells – Sept. 2021
Rapid initiation of nasal saline irrigation to reduce severity in high-risk COVID+ outpatients: a randomized clinical trial compared to a national dataset observational arm – 2021
Xylitol Blocks Viral Adhesion: Study on Human Airway Tissue – 2021
Researchers at Utah State University performed research to show that xylitol blocked viral adhesion on human airway tissue. Though a similar study was performed previously using industry standards (performed on vero kidney tissue), the FTC required a higher-standard study to show efficacy. This study using that higher standard, shows that xylitol and other sugar alcohols block adhesion of different viruses to different degrees.
Jung, Kie Hung. (2021). Antiviral Efficacy Against Virus Infections in Human-Derived Tracheal/Bronchial Epithelial Cells. Utah State University.
Can the Nasal Cavity Help Tackle COVID-19? – 2021
In this review, the authors set out to organize and summarize all the information now available for COVID-19 therapies, specifically those therapies which are administered through the nose. The article has an entire section (5.1) which goes over research supporting Xlear. The authors conclude, “The nasal route has been proposed as a promising strategy to deliver vaccines and agents known to have antiviral properties against SARS-CoV-2. Tremendous efforts are put into developing safe, efficacious, and stable formulations. In the context of the COVID-19 pandemic, it is of crucial importance to have powerful strategies to rely on.”
Pilicheva, B., & Boyuklieva, R. (2021). Can the Nasal Cavity Help Tackle COVID-19? Pharmaceutics, 13(10).
Role of Natural Grapefruit Seed Extract Against SARS-CoV-2 – 2021
Researchers wanted to study the effect grapefruit seed extract had on SARS-CoV-2 to see if it was a potential inhibitor of molecular docking. Using in silico method they found that, “antiviral activity of grapefruit extract, both fractional and combined suggest it could be used as a highly biologically potent adjuvant treatment for COVID-19.” An adjuvant is a substance used to increase the efficacy or potency of a drug or treatment. The study also made an important conclusion that natural extracts “have proven to be more effective as treatment (antibacterial or cytotoxic) than synthetically obtained pure derivatives.”
Saric, B., Tomic, N., Kalajdzic, A., Pojskic, N., & Pojskic, L. (2021). In silico analysis of selected components of grapefruit seed extract against SARS-CoV-2 main protease. The EuroBiotech Journal, 5(s1), 5–12.
Medical Disclaimer per FTC Guidelines
While there may be information on the Xlear website relating to certain conditions, including COVID, cold, flu and similar condition, should a medical condition exist, promptly see your own physician or health provider. Xlear does not offer medical diagnosis or treatment advice. Xlear makes no claims that it can cure, treat or prevent any conditions, including any conditions referenced on its website or in print materials, including COVID, cold, flu and similar condition. The information, including any scientific or clinical research, is made available for educational purposes only. This information helps people make informed decisions about potential treatment options for the various conditions referenced in the information. Xlear therefore makes every effort to ensure that any information it shares complies with national and international standards for clinical trial information and is committed to the timely disclosure of the design and results of all interventional clinical studies for innovative treatments available or that may be made available. However, research is not considered conclusive. Always consult your healthcare provider with any questions.
If you take prescription medications for any of these conditions or other conditions, including sinus and related conditions such as congestion, you should consult with your physician before discontinuing use of such medications as Xlear is not intended to replace or supplement any prescription medications.
Statements with regards to Xlear products are the opinions of the individuals making them and are not necessarily the same as those of Xlear Inc.
Xlear Inc. Statement on FTC Guidelines
Recently Xlear has removed a number of scientific studies and posted disclaimers on our website and social media. We have done this at the insistence of the Federal Trade Commission. We believe the FTC has no authority to stop us from giving you accurate scientific information. Moreover, the FTC lacks the scientific/medical expertise to evaluate such data. However, we are trying to work with the FTC to fix this.
We believe that you have a right to accurate and actionable scientific studies and data. We believe that accurate scientific data and studies are vital in helping individuals make smart and informed health decisions for themselves and their families.