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Science Behind Xlear Products

Foundational Studies

These studies demonstrate the benefits of using xylitol in sinus care products, the foundation of Xlear Sinus Care.

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Anti-Adherence of Bacteria – 1998

This study found that xylitol blocked adhesion of bacteria to epithelial cells, showing that xylitol inhibits bacteria from sticking to tissue, which allows the body to wash them away.

Kontiokari, T., Uhari, M., & Koskela, M. (1998). Antiadhesive effects of xylitol on otopathogenic bacteria. The Journal of Antimicrobial Chemotherapy, 41(5), 563–565.

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Xylitol Nasal Irrigation in the Management of Chronic Rhinosinusitis – 2011

In this pilot study, researchers wanted to find out if irrigating the sinuses with a water-xylitol solution would improve symptoms of people suffering from chronic rhinosinusitis. They concluded, “Xylitol irrigations result in greater improvement of symptoms of chronic rhinosinusitis as compared to saline irrigation.”
Weissman, J. D., et al. (2011). Xylitol nasal irrigation in the management of chronic rhinosinusitis: a pilot study. The Laryngoscope, 121(11), 2468–2472.
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Airway Study – 2015

In a 2015 presentation, Dr. Nsouli shared his findings of a study which showed that a nasal spray with xylitol increased peak airflow 35% more than saline alone and measurably increased participants’ quality of life.

Nsouli, T. M.; et al., (2015) ORAL ABSTRACT #46.

Improved Nasal Volume Utilizing Hyperosmotic Saline Xylitol Mixture (Effective Alternative or Adjunct to Decongestants and Antihistamines) – 2019

In this article Drs. Olmos and Baba discuss their findings which showed that 3 minutes after spraying participants’ noses with a saline and xylitol spray, they experienced a  20% improvement in airway volume.
Olmos, S., Baba, J., (2019.). Improved Nasal Volume Utilizing Hyperosmotic Saline Xylitol Mixture (Effective Alternative or Adjunct to Decongestants and Antihistamines). EC Pulmonology and Respiratory Medicine 8.5, 444-452.
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Xylitol Blocks Viral Adhesion: Study on Human Airway Tissue – 2021

Researchers at Utah State University performed research to show that xylitol blocked viral adhesion on human airway tissue. Though a similar study was performed previously using industry standards (performed on vero kidney tissue), the FTC required a higher-standard study to show efficacy. This study using that higher standard, shows that xylitol and other sugar alcohols block adhesion of different viruses to different degrees.

Jung, Kie Hung. (2021). Antiviral Efficacy Against Virus Infections in Human-Derived Tracheal/Bronchial Epithelial Cells. Utah State University.

User Experience with a Gentle Spray Nozzle – 2022

Researchers wanted to see if using a nozzle that sprayed a gentler mist for nasal sprays would improve the user experience and thus compliance. They found that a specific nozzle, the one used on Xlear Nasal Spray, provided an “unequivocally favorable experience.”

Basu, S., Khawaja, U., Rizvi, S., Sanchez-Gonzalez, M., & Ferrer, G. (2022). Evaluation of Patient Experience for a Computationally-Guided Intranasal Spray Protocol to Augment Therapeutic Penetration: Implications for Effective Treatments for COVID-19, Rhinitis, and Sinusitis. Medical Research Archives, 10(4).

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Medical Disclaimer per FTC Guidelines

While there may be information on the Xlear website relating to certain conditions, including COVID, cold, flu and similar condition, should a medical condition exist, promptly see your own physician or health provider. Xlear does not offer medical diagnosis or treatment advice. Xlear makes no claims that it can cure, treat or prevent any conditions, including any conditions referenced on its website or in print materials, including COVID, cold, flu and similar condition. The information, including any scientific or clinical research, is made available for educational purposes only. This information helps people make informed decisions about potential treatment options for the various conditions referenced in the information. Xlear therefore makes every effort to ensure that any information it shares complies with national and international standards for clinical trial information and is committed to the timely disclosure of the design and results of all interventional clinical studies for innovative treatments available or that may be made available. However, research is not considered conclusive. Always consult your healthcare provider with any questions.
If you take prescription medications for any of these conditions or other conditions, including sinus and related conditions such as congestion, you should consult with your physician before discontinuing use of such medications as Xlear is not intended to replace or supplement any prescription medications.
Statements with regards to Xlear products are the opinions of the individuals making them and are not necessarily the same as those of Xlear Inc.

Xlear Inc. Statement on FTC Guidelines

Recently Xlear has removed a number of scientific studies and posted disclaimers on our website and social media. We have done this at the insistence of the Federal Trade Commission. We believe the FTC has no authority to stop us from giving you accurate scientific information. Moreover, the FTC lacks the scientific/medical expertise to evaluate such data. However, we are trying to work with the FTC to fix this.

We believe that you have a right to accurate and actionable scientific studies and data. We believe that accurate scientific data and studies are vital in helping individuals make smart and informed health decisions for themselves and their families.